---
title: Engineered Heart Tissue from iPSC-Cardiomyocytes | Propria
description: Propria offers new technology for creating robust engineered heart tissues from iPSC-derived cardiomyocytes. Tissue contractility is measured automatically with our MyoPod analyzer. Applications include drug discovery, cardiotoxicity testing, and basic cardiac research.
---

# Perfecting In Vitro Cardiac Contractility to Better Predict Human Physiology.

 

 

## What We Do

Propria conducts *in vitro* cardiac contractility testing of disease models and new therapeutics. Scientists and pharmaceutical companies send their new compounds or gene therapies directly to Propria for one of our detailed testing services:

[![Atrial-Ventricular](https://www.propriabio.com/hs-fs/hubfs/Atrial-Ventricular.jpg?width=700&height=505&name=Atrial-Ventricular.jpg "Atrial-Ventricular")](https://propriabio-21233446.hs-sites.com/contractile-profiling?hs_preview=UTpsiKky-63702053175&previewJwt=eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.eyJpc19wcmV2aWV3X2F1dGhlZCI6dHJ1ZSwiZXhwIjoxNjQyMjgxNjQ5fQ.04ySXUXeGjfEWQdnJdP6Oz-Z7B_UV_IAoINTIUPbPeo&hsLang=en)

### Contractile Profiling

Comprehensive *in vitro* cardiac contractility  
to better predict human pharmacology.

[ Learn More ](https://www.propriabio.com/contractile-profiling?hsLang=en)

[![LDA-Panel---2](https://www.propriabio.com/hs-fs/hubfs/LDA-Panel---2.jpg?width=700&name=LDA-Panel---2.jpg "LDA-Panel---2")](https://propriabio-21233446.hs-sites.com/functional-cardiac-reserve?hs_preview=CrOgpzAL-63703412810&previewJwt=eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.eyJpc19wcmV2aWV3X2F1dGhlZCI6dHJ1ZSwiZXhwIjoxNjQyMjgxNjY3fQ.qGk92d663M7Rllk_5q5UkIPmpOjP_4m9_goo5n4smF0&hsLang=en)

### Functional Cardiac Reserve

Deeper insights into cardiac function and  
physiological adaptability.

[ Learn More ](https://www.propriabio.com/functional-cardiac-reserve?hsLang=en)

![MyoLab_Twitch_Animation-1](https://www.propriabio.com/hs-fs/hubfs/MyoLab_Twitch_Animation-1.gif?width=400&height=231&name=MyoLab_Twitch_Animation-1.gif "MyoLab_Twitch_Animation-1")

#### **Stop missing the full picture**

Propria has developed a new class of human engineered heart tissues (hEHTs) that enable **comprehensive contractile profiling with unprecedented realism and technical rigor**. We are cardiac muscle physiologists with an extraordinary commitment to understanding and recapitulating muscle function. This has culminated in a system that produces **incredibly rich yet simple-to-digest datasets** which enable you to see the full contractile profile of human tissues.

#### **Harness the power of realistic human twitch behavior**

Propria hEHTs possess both a cellular composition that closely resembles that of the adult human myocardium and isometric twitch kinetics that mimic human data more reliably than rodent model systems. This realistic human twitch results **in meaningful and predictive data**, de-risking compounds earlier in the drug discovery process.

![Propria Beating Heart Tissue-1](https://www.propriabio.com/hubfs/Propria%20Beating%20Heart%20Tissue-1.gif "Propria Beating Heart Tissue-1")

![12-well-1](https://www.propriabio.com/hubfs/12-well-1.gif "12-well-1")

#### **Better tissue design means more reliable data**

Accurate profiling of treatment regimes is technically demanding, and Propria scientists have spent years refining the design of our hEHTs and specialized instrumentation to produce robust and replicable datasets. Importantly, Propria hEHTs are thin, ribbon-like structures that are **within the diffusion limit of oxygen** – enabling us to achieve longer-term contractility testing than possible with other EHT systems. Built-in quality control metrics of tissue performance ensure **accurate, reliable, and consistent** characterization.

#### **Get input from cardiac muscle experts**

Propria’s services not only offer comprehensive contractility data outputs, but also include **data analysis and interpretation **by highly-trained PhD-level scientists with many years of experience in cardiac muscle physiology.

![Cardiac-Muscle-Experts-1](https://www.propriabio.com/hubfs/Cardiac-Muscle-Experts-1.gif "Cardiac-Muscle-Experts-1")

## Request Information

### If you have any questions or would like more information about Propria, please fill out the form below.